Agaricus Blazei Mushrooms (Agaricus Subrufescens)

STUDY 1

Antineoplasic activity of Agaricus brasiliensis basidiocarps on different maturation phases

Abstract

Apium graveolens Linn. (Karafs) is used in traditional medicine for the treatment of the various ailments. There is a need to explore and authenticate the pharmacological profile and medicinal importance of the Karafs. In this paper, the literature and the published work on Apium were collected using online resources “Google scholar”, “Web of science”, “Scopus” and “PubMed”. Each of the pharmacological activity was searched individually using the keywords “Apium/Karafs/Apium graveolens + individual pharmacological activity”. We documented the most cited and most recent literatures. The current findings illuminate the importance Karafs in the traditional medicine and their impact in treating various diseases. This review strongly supports the fact that the Apium has emerged as a good source of medicine in treating various diseases. There is also a need to isolate the bioactive phytochemicals present in this plant.

Conclusion

The ancient literature and the practice among the local population clearly indicate that herbal medicine is being practiced in the Arab region since long back.

In this review, we documented the medicinal importance of the A. graveolens (Karafs) that is being used as anthelmintic, antispasmodic, carminative, diuretic, laxative, sedative stimulants in the Arab traditional medicine. The description of the plants and its medicinal importance as per the old Arab literature has been summarized. In addition, the phytochemical investigation the pharmacological activity which has been carried out so far has been summarized.

There is a need to preserve the pharmacological profile and the medicinal importance of the Karafs. There is also need to isolate the bioactive phytochemicals that are present in the plants. Karafs needs effective utilization to make a hallmark to treat the various diseases and to be available for ordinary population.

STUDY 2
The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation

Abstract

The medicinal mushroom Agaricus blazei Murill from the Brazilian rain forest has been used in traditional medicine and as health food for the prevention of a range of diseases, including infection, allergy, and cancer. Other scientists and we have examined whether there is scientific evidence behind such postulations. Agaricus blazei M is rich in the immunomodulating polysaccharides, β-glucans, and has been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties in mouse models, in addition to anti-inflammatory effects in inflammatory bowel disease patients. These effects are mediated through the mushroom’s stimulation of innate immune cells, such as monocytes, NK cells, and dendritic cells, and the amelioration of a skewed Th1/Th2 balance and inflammation.

Conclusion

The medicinal mushroom Agaricus bM has been shown to have beneficial effects on a range of diseases including cancer, infections, allergy/asthma, and inflammatory disorders. The explanation is the mushroom’s engagement of innate immunity, which is “broad-spectered.” When adaptive immunity then is engaged through the stimulation of DC, it results in an enhanced Th1 antitumor and anti-infection response relative to the proallergic Th2 response. Thus, AbM ameliorates the Th2-skewed balance found in advanced cancer, mycobacterial infections and allergy and asthma. In addition, there may be a general anti-inflammatory effect of AbM, which may be therapeutical for inflammatory bowel diseases and augment the mushroom’s antitumor and antiallergy/antiasthma properties. Hence, AbM extract may show promise as a prophylacticum and as an additive treatment for quite different and some serious diseases.

STUDY 3
Antineoplasic activity of Agaricus brasiliensis basidiocarps on different maturation phases

Abstract

The fungus Agaricus brasiliensis is a Basidiomycete studied because of its immunomodulation and/or antitumor substances. The objective of this study was to verify the Agaricus brasiliensis antineoplasic activity in vivo on different basidiocarp maturation phases on Sarcoma 180 cells implanted in mice. Sarcoma cells were implanted in mice and after seven days mice were divided in three groups. The first group was treated with saline solution, the second group was treated with closed basidiocarp extract solution and the third group was treated with opened basidiocarp extract solution. After 30 days of being daily orally treated with these three solutions all animals suffered euthanasia, and the splenic index, tumor mass and volume were determined. No significant differences of the tumor growth inhibition in function of the different basidiocarp maturation phases for the Agaricus brasiliensis strain were observed. The in vivo basidiocarp antineoplasic average activity was 89.22%.

Conclusion

In conclusion, our results suggest that there are no significant differences of tumor growth inhibition in function of different basidiocarp maturation phases for the Agaricus brasiliensis strain, being the in vivo basidiocarp antineoplasic activity average of 89.22%. These findings will contribute to the development of the biological activity research on Agaricus brasiliensis strains.

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Agaricus Blazei Capsules

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Agaricus Blazei has long been revered for its immune and cell-supporting properties.It provides immune system boost, cardiovascular benefits, healthy digestion support, blood sugar regulation, and cholesterol level control, as well as, weight stability